Online JudgeProblem SetAuthorsOnline ContestsUser
Web Board
F.A.Qs
Statistical Charts
Problems
Submit Problem
Online Status
Prob.ID:
Register
Authors ranklist
Current Contest
Past Contests
Scheduled Contests
Award Contest
Register

Language:
DNA Sequence Alignment
 Time Limit: 25000MS Memory Limit: 65536K Total Submissions: 2743 Accepted: 307 Case Time Limit: 5000MS

Description

Gnaileux Iew is attracted in Bioinformatics recently. He reads papers day and night and devotes all his mind in studying. Today he is going to review the basic problem in Bioinformatics: DNA sequence alignment. His purpose is to find a simple and effective algorithm that performs global alignment with two highly similar DNA sequences.

A DNA sequence is presented as a sequence of characters, which may be 'A', 'G', 'C' or 'T'. To align two DNA sequences, some gaps may be inserted to sequences so that two sequences have the same length. And then it is counted up for every pair of matched characters by a score matrix. Gnaileux Iew uses a minimal-score matrix hence the total score of alignment should be minimized. Following is the score matrix Gnaileux Iew uses:

For example, an alignment for DNA sequences "AAGACG" and "CAGAGCTC" may be:
-AAGA-C-G
CA-GAGCTC
The total score is 3+0+3+0+0+3+0+3+4=16.

Gnaileux Iew is only interested in aligning highly similar sequences. Strictly speaking, |LCS(A,B)| * 2 / (|A |+ |B|) >= 90%, where A and B are the sequences to align, and LCS(A,B) is the longest common subsequence of A and B.

Input

Input contains multiple test cases. Each test case contains two lines, which are the two DNA sequences to align. DNA sequences contain only characters 'A', 'G', 'C' and 'T'. The length of each sequence is not greater than 50000.

You can assume that all the input cases are highly similar sequences.

Output

For each test case print the minimal total score of alignment in one line.

Sample Input

```AGTGCTGAAAGTTGCGCCAGTGAC
AGTGCTGAAGTTCGCCAGTTGACG
CACAATTTTTCCCAGAGAGA
CGAATTTTTCCCAGAGAGA
```

Sample Output

```12
7
```

Source

[Submit]   [Go Back]   [Status]   [Discuss]